Alteration of hepatic ornithine decarboxylase and aniline hydroxylase activities following a single dosing of azathioprine to rats.
نویسندگان
چکیده
Hepatic ornithine decarboxylase and aniline hydroxylase activities increased as early as 6h after a single dosing of azathioprine tomale rats and reached maximum levels at the 12th h after the treatment. However, aniline hydroxylase activity dropped to levels mu lower than the cintrols 48 h following azathioprine treatment. The results are discussed with regard to the role of azqathioprine during the promotion of hepatocarcinogenesis.
منابع مشابه
Chloroform induction of ornithine decarboxylase activity in rats.
Chloroform is a drinking water contaminant that has been demonstrated to be carcinogenic to mice and rats resulting in an increased incidence of liver and kidney tumors, respectively. The mechanism of chloroform carcinogenicity might be by tumor initiation and/or promotion. Since induction of ornithine decarboxylase (ODC) activity has been proposed as a molecular marker for tumor promoters, we ...
متن کاملProtective role of fructose 1,6-bisphosphate during CCl4 hepatotoxicity in rats.
Rats were injected intraperitoneally with CCl4 (2.5 ml/kg body wt.) and the hepatotoxicity was compared with that of rats receiving the same dose of CCl4 and an intraperitoneal injection of fructose 1,6-bisphosphate (2 g/kg body wt.). A 50-70% decrease in plasma aspartate aminotransferase and alanine aminotransferase activities was observed in the latter treatment, indicating a protective role ...
متن کاملEffects of 5-FluorouraciI on Drug-metabolizing Enzymes in the Rat1
The effect of pretreatment of rats with 5-fluorouracil (5-FU) on hepatic drug-metabolizing enzyme activities was examined. Male rats, weighing 165g, were given a single i.p. injection of 5-FU, 120 mg/kg, and 7 days later the drug-metabolizing enzyme activities of a 10,000 x g supernatant fraction from liver homogenates were exam ined. Aniline hydroxylase, ethylmorphine /V-demethylase, and 2-(me...
متن کاملEffects of 5-fluorouracil on drug-metabolizing enzymes in the rat.
The effect of pretreatment of rats with 5-fluorouracil (5-FU) on hepatic drug-metabolizing enzyme activities was examined. Male rats, weighing 165g, were given a single i.p. injection of 5-FU, 120 mg/kg, and 7 days later the drug-metabolizing enzyme activities of a 10,000 x g supernatant fraction from liver homogenates were exam ined. Aniline hydroxylase, ethylmorphine /V-demethylase, and 2-(me...
متن کاملEffect of Polycyclic Aromatic Compounds and Phorbol Esters on Ornithine Decarboxylase and Aryl Hydrocarbon Hydroxylase Activities in Mouse
Single i.p. injections of 3-methylcholanthrene (MC; 50 mg/ kg) administered to inbred C57BL/6 mice or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 100 /~g/kg) to DBA/2 mice gave an increase in the hepatic activities of ornithine decarboxylase (ODC) and aryl hydrocarbon hydroxylase (AHH) with peaks occurring by 12 and 48 hr, respectively. A single i.p. dose of the tumor promoter 12-O-tetradecanoyl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Acta medica Okayama
دوره 36 4 شماره
صفحات -
تاریخ انتشار 1982